Insufficient sleep and circadian disruption
Insufficient and/or poor-quality sleep can have severe consequences for our health, performance and safety. Sleep disruption occurs in both working and clinical populations where it may be an indicator or driver of disease progression.
Overview
Sleep disturbance can take many forms and includes acute sleep deprivation/extended wakefulness, being abruptly awoken (e.g., emergency responders), and chronic sleep restriction. In addition, circadian misalignment, where the circadian clock is inappropriately aligned with the desired sleep/wake schedule, as occurs in shift work and jet lag, also results in short, poor quality sleep episodes. Insufficient or mistimed sleep and/or operating at an adverse circadian phase not only impacts both physical and cognitive performance but may have safety implications as it can lead to poor decision-making and slower reaction times.
We are concerned with assessing the prevalence of sleep disruption in emergency responder/military populations as well as the development and testing of interventions to improve sleep/circadian rhythms in operational and clinical settings, including administration of specific lighting and caffeine.
Selected publications
Muto V, Jaspar M, Meyer C, Kussé C, Chellappa SL, Degueldre C, Balteau E, Shaffii-Le Bourdiec A, Luxen A, Middleton B, Archer SN, Phillips C, Collette F, Vandewalle G, Dijk DJ, Maquet P. . Science. 2016 Aug 12;353(6300):687-90. doi: 10.1126/science.aad2993. Erratum in: Science. 2016 Dec 23;354(6319):null. PMID: 27516598.
Skorucak J, Arbon EL, Dijk DJ, Achermann P. Sleep. 2018 Jul 1;41(7). doi: 10.1093/sleep/zsy078. PMID: 29722893.
Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1132-41. doi: 10.1073/pnas.1217154110. Epub 2013 Feb 25. PMID: 23440187; PMCID: PMC3607048.
Archer SN, Laing EE, Möller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E682-91. doi: 10.1073/pnas.1316335111. Epub 2014 Jan 21. PMID: 24449876; PMCID: PMC3926083.
Laing EE, Johnston JD, Möller-Levet CS, Bucca G, Smith CP, Dijk DJ, Archer SN. Bioessays. 2015 May;37(5):544-56. doi: 10.1002/bies.201400193. Epub 2015 Mar 14. PMID: 25772847; PMCID: PMC5031210.
Loomis S, McCarthy A, Dijk DJ, Gilmour G, Winsky-Sommerer R. . Sleep. 2020 Oct 13;43(10):zsaa079. doi: 10.1093/sleep/zsaa079. PMID: 32518958; PMCID: PMC7551307.
Nollet M, Hicks H, McCarthy AP, Wu H, Möller-Levet CS, Laing EE, Malki K, Lawless N, Wafford KA, Dijk DJ, Winsky-Sommerer R. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2733-2742. doi: 10.1073/pnas.1816456116. Epub 2019 Jan 25. PMID: 30683720; PMCID: PMC6377491.
